GlobalData estimated that the global polycystic ovarian syndrome market (PCOS) was valued at $706m in 2009 and forecasts it to shrink by 0.8% annually for the next seven years. The growth rate from 2001-09 was 6.8%. The patent of Letrozole will expire in the year 2011. As a result, the market will shrink by 30.1% and will come down to $562m in 2012.
The market will start growing from 2013 due to the increase in disease prevalence and prescription rates and will rise to $702m in 2016. The CAGR from 2009-16 will be -0.8%.The "experts" can't be honest and straight forward about exactly what caused this. It's not caused by insulin resistance or obesity. PCOS has an immune/metabolic origin. Birth control, Metformin and Clomid don't meet these needs. The "pipeline" they referred to, aka. the doctors or the "pill pushers" who prescribe these drugs.This slow growth rate is primarily due to the presence of a large number of generic drugs in the market and the absence of effective pipeline molecules. However, the treatment seeking and diagnosis rates will also boost the PCOS market to some extent. Hence, the overall PCOS market will have very slow growth in the upcoming years.
Current Market Unsuccessful in Meeting Existing Market Need
GlobalData found that the existing drugs are not serving the market sufficiently.
The current competition in the PCOS market is weak and due to the fact that there are relatively few marketed products, there is a high level of unmet need. In 2009, the unmet need was approximately $233m. Although the currently marketed and off-label products possess high safety profiles, they lack significant efficacy profiles. This creates a huge unmet need in the market. Thus, there is huge market potential for new entrants that can take advantage of this scenario by introducing products that are more efficacious than the existing products.
(hint:)The oral contraceptive market is $8 BILLION/year
Physician Payments Sunshineprovisions in Health Care ReformThe Physician Payments Sunshine provisions in health care reform legislationrequire drug and medical device manufacturers to publicly report gifts andpayments made to physicians and teaching hospitals.The Physician Payment Sunshine provisions were included in the Patient Protectionand Affordable Care Act of 2009 (H.R. 3590, section 6002) which was signed intolaw on March 23, 2010.
I'm very frustrated with the lie that modern medicine became. People are angry with me because of my symptoms, which I have seen THREE doctors for in the last year. I can't control my symptoms. However, the publicized bad information regarding this disease is making life harder to nearly impossible for the patient.
"A major US clinical trial lasting nearly three years called the Diabetes Prevention Program (DPP) had already found diabetes in high-risk adults was reduced by 58% with “intensive lifestyle intervention”, and by 31% with metformin, compared with a placebo.
The study involved around 3,000 participants. About a third were initially asked to eat a low-fat diet and take at least 30 minutes of moderate activity a minimum of five times a week, with the aim of losing 7% of their body weight within a year. Another third were put on metformin; the rest initially received no treatment or advice.
Now, in a 10 year follow-up study, the researchers have investigated whether these effects made a long term difference.
Diet and exercise more effective than drugs
The findings are published in an article online, ahead of the print edition of The Lancet, by Dr William Knowler of the US National Institute of Diabetes and Digestive and Kidney Diseases, and colleagues from the Diabetes Prevention Program Research Group.
The original lifestyle changes group lost an average of seven kilograms (15.4 pounds) of body weight, then put some of it back on, levelling out at an averageweight loss of two kilograms (4.4 pounds); but this group still had the lowest rates of diabetes."
There is confusion as to whether AHA/NHLBI intended to create another set of guidelines or simply update the NCEP ATP III definition. According to Scott Grundy, University of Texas Southwestern Medical School, Dallas, Texas, the intent was just to update the NCEP ATP III definition and not create a new definition.[6][7]:
- Elevated waist circumference:
- Men — Equal to or greater than 40 inches (102 cm)
- Women — Equal to or greater than 35 inches (88 cm)
- Elevated triglycerides: Equal to or greater than 150 mg/dL (1.7 mmol/L)
- Reduced HDL (“good”) cholesterol:
- Men — Less than 40 mg/dL (1.03 mmol/L)
- Women — Less than 50 mg/dL (1.29 mmol/L)
- Elevated blood pressure: Equal to or greater than 130/85 mm Hg or use of medication for hypertension
- Elevated fasting glucose: Equal to or greater than 100 mg/dL (5.6 mmol/L) or use of medication for hyperglycemia
My LDL is low (97 for PCOS) and my HDL is only 57 (40 is the lowest until it's called a "problem"). When I had these tests done, my BMI was 18.3 (right beneath the "Normal Weight" range). So although my waistline swells due to cramps, it's not that big.
In the sucrose group, there was an increase of a little more than 400 calories, which would result in an approximate weight gain of almost seven pounds during the 10-week study if all other factors were constant. However, there was only about half that weight gain in this group. Therefore, the authors estimate that 48 percent of the excess energy intake from sucrose was used for other energy-demanding body processes, such as lipogenesis (the creation of fat).
To make matters worse, fructose consumption is tied to insulin resistance in rodents and increased triglyceride secretion (suggesting that it may have the same effect on humans, too). Considering that type 2is a common co-morbidity of overweight and obesity, insulin resistance is common. Therefore, if fructose does, in fact, have the same insulin-resistant effect in humans as it does in rodents, individuals would be exacerbating the issue by consuming too much of it.http://www.diabeteshealth.com/read/2008/08/20/4274/the-dangers-of-high-fructose-corn-syrup/
HFCS linked to obesity.
http://journal.shouxi.net/qikan/article.php?id=390646
In laboratory animals, fructose has been shown to cause insulin resistance and induce obesity by affecting the part of the brain known as the hypothalamus. The HYPOTHALAMUS, many believe, can sense the nutrients in foods animals eat and trigger metabolic responses. For example, if the hypothalamus senses an abundance of fructose, it stimulates a sense of hunger, which leads to the animals eating more and gaining excess weight.
In those same laboratory animals, pure glucose, or sugar, does not appear to incite the desire to eat more.
The role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity.
Department of Medical Biochemistry, University of Calgary, AB, Canada.
Abstract
Gonadal steroids play an important role in the development and regulation of the immune system. Their effects may be mediated through a thymus-hypothalamus-pituitary-gonadal axis. The thymus gland secretes factor(s), including thymosin beta 4, that affect the release of gonadotropin releasing hormone (GnRH). GnRH regulates the subsequent release of luteinizing hormone, thereby affecting early ovarian development. Thymic factors may be modulated by gonadal steroids. Studies indicate that levels of thymosin beta 4 decrease in postmenopausal and ovariectomized women. In diseases such as systemic lupus erythematosus, abnormal patterns of estrogen metabolism may affect thymic function and contribute to the etiology of the disease.
"A study of female mice is suggesting that ovarian cysts may at least partially be the result of an immune system dysfunction. The gland involved is the thymus gland, which is responsible for the management of major aspects of your immune system. One of the functions of the thymus gland is to produce T-cells, which are white blood cells that help protect you from infection and also perform other important activities.
THE RESEARCHERS REPORTED THAT THE OVARIAN CYSTS IN THE FEMALE MICE DID NOT DEVELOP UNLELSS THERE WAS AN ABSENCE OF REGULATORY T-CELLS. http://www.ovarian-cysts-pcos.com/news81.html
When the level of thyroid hormones (T3 & T4) drops too low, the pituitary gland produces Thyroid Stimulating Hormone (TSH)which stimulates the thyroid gland to produce more hormones. Under the influence of TSH, the thyroid will manufacture and secrete T3 and T4 thereby raising their blood levels. The pituitary senses this and responds by decreasing its TSH production. One can imagine the thyroid gland as a furnace and the pituitary gland as the thermostat. Thyroid hormones are like heat. When the heat gets back to the thermostat, it turns the thermostat off. As the room cools (the thyroid hormone levels drop), the thermostat turns back on (TSH increases) and the furnace produces more heat (thyroid hormones).
The pituitary gland itself is regulated by another gland, known as the hypothalamus (shown in our picture in light blue). The hypothalamus is part of the brain and produces TSH Releasing Hormone (TRH) which tells the pituitary gland to stimulate the thyroid gland (release TSH). One might imagine the hypothalamus as the person who regulates the thermostat since it tells the pituitary gland at what level the thyroid should be set.http://www.endocrineweb.com/conditions/thyroid/how-your-thyroid-works
Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years.
Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J.
Section of Endocrinology, Department of Internal Medicine, Esbjerg County Hospital, Oerum Health Centre, University of Southern Denmark, Esbjerg, Denmark. jkv@ribeamt.dk
Abstract
OBJECTIVE: Mild thyroid failure is associated with an increased risk for development of atherosclerosis, but whether subclinical hypothyroidism is related to risk for cardiovascular disease is controversial. The purpose of the present study was to examine a possible association between subclinical hypothyroidism and cardiovascular disease....
"Pituitary and hypothalamic disease affects the amount of thyroid hormone made and secreted by the thyroid gland and causes hypothyroidism. Secondary hypothyroidism is the condition of hypothyroidism caused pituitary disease, while tertiary hypothyroidism is caused by hypothalamic disease.
- Severe form of Iodine deficiency also causes hypothyroidismin mountainous areas of poor, less industrialized nations." (or by iodine blockers ie. bromide/perchlorates/fluoride)
Before lymphocytes join the fight against infection, they must first learn the difference between self and non-self. Many T and B cells fail to meet the body’s quality standards and are destroyed before being released into the circulation.
Women with PCOS present increased serum AGE levels, which are acutely elevated after intake of a single meal high in AGE content. In this study the effects of a hypocaloric diet and an AGE-enriched hypocaloric diet were investigated, on the endocrine and metabolic profile of PCOS women.
Eleven women with PCOS, defined by Rotterdam criteria, were assigned for two months to a hypocaloric regular diet followed by two months of a hypocaloric AGE-enriched diet. At the end of each period endocrine parameters were determined.
PCOS women on hypocaloric diet showed a significant reduction on BMI (P=0.0276), which was followed by a significant reduction on HOMA (P=0.0035), but not significant changes on AGEs (P=0.6073) or Testosterone concentrations (P=0.7857). In post hypocaloric-AGE-enriched diet, without significant changes in BMI (P=0.29) and HOMA (P=0.1560), testosterone levels (P=0.0007) were increased in comparison to their status during hypocaloric diet and to baseline. Additionally, the difference of AGEs levels from hypocaloric diet to high AGEs diet were significantly higher (P=0.0312).
Increased dietary intake of AGEs in hypocaloric diet is associated with significant increases in androgen levels, contributing to abnormal hormonal profile in women with PCOS. Since in the ovarian compartments from polycystic ovarian tissue the AGE and their receptor RAGE have been determined immunochemically, the role of dietary AGEs in PCOS needs to be explored http://www.endocrine-abstracts.org/ea/0016/ea0016p171.htm
"In conclusion, it is demonstrated that excess dietary glycotoxins in experimental animals appeared to be accumulated in the ovarian tissues and are also associated with metabolic and hormonal alterations.”
http://www.springerlink.com/content/g872k677v1114520/
Abstract
OBJECTIVE: To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS).
DESIGN: Observational study.
SETTING: Obese women with PCOS in an academic research environment.
PATIENT(S): Fifteen obese women (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study.
INTERVENTION(S): Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol.
MAIN OUTCOME MEASURE(S): Peripheral insulin resistance and insulin effectiveness were estimated with minimal model.
RESULT(S): The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile.
CONCLUSION(S): Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.
So after going in circles between diabetes, hypothyroidism and glycation, it all boils down to this (and it makes perfect sense in the sphere of things).
We're deficient in iodine. Iodine deficiency causes metabolic syndrome (Insulin Resistance).
[Correlation between adipocytokines with iodine deficiency criteria in patients with metabolic syndrome and type 2 diabetes mellitus in Carpathians region].
[Article in Ukrainian]
Abstract
69 patients with metabolic syndrome (MS) and type 2 diabetes mellitus (DM) have been examined. It is certain that activation of the cytokines system plays important part in formation of the insulin resistance syndrome. The results of our studies testify that insulin resistance in patients with MS and type 2 DM is associated by the decrease in the level of adiponectin and increase in the level of resistin. Lower level of adiponectin and higher level of resistin in blood serum can be examined as markers of the metabolic syndrome. Content of adiponectin in blood serum negatively correlates with an insulin resistance index HOMA IR, the level of TSH, proinflammatory cytokines-tumor necrosis factor alpha (TNFa) and cortisol. The author showed direct correlations between the TSH level and proinflammatory cytokines--TNFalpha, IL-6, CRP and negative correlations between HOMA IR indexes and iodinuria. It indicates on the connection of insulin resistance with the iodine deficiency in biosphere.
Résumé / Abstract
Background Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels and other tissues in diabetic state and in euglycaemic conditions with increased oxidative stress. Insulin resistant (IR) polycystic ovary syndrome (PCOS) women, have elevated serum AGEs, increased receptor (RAGE) expression, and increased deposition with differential localization in the polycystic ovarian tissue (theca and granulosa) compared to normal. Objective To determine whether the raised AGE levels in noninsulin resistant women with PCOS is a distinct finding compared with those presenting the isolated components of the syndrome and among PCOS subphenotypes. Noninsulin resistant women were selected in order to show that serum AGEs are elevated in PCOS independently of the presence of IR. Design Clinical trial. Patients One hundred and ninety-three age- and BMI-matched young lean noninsulin resistant women were studied. Among them, 100 women were diagnosed with PCOS according to Rotterdam criteria, and divided to subphenotypes (hyperandrogenaemia with or without PCO morphology and with or without anovulation). Sixty-eight women with the isolated components of the PCOS phenotype were also studied along with 25 healthy women. Measurements Serum AGE levels, metabolic, hormonal profiles and intravaginal ultrasound were determined in all subjects. Results The studied population did not differ in BMI, fasting insulin concentration, waist: hip and glucose : insulin ratios. PCOS women exhibited statistically higher AGEs levels (7·96 ± 1·87 U/ml, P <>As chronic inflammation and increased oxidant stress have been incriminated in the pathophysiology of PCOS, the role of AGEs as inflammatory and oxidant mediators, may be linked with the metabolic and reproductive abnormalities of the syndrome.
"Obesity causes PCOS and diabetes"
"I will remember that there is art to medicine as well as science, and that warmth, sympathy, and understanding may outweigh the surgeon's knife or the chemist's drug.I will not be ashamed to say "I know not," nor will I fail to call in my colleagues when the skills of another are needed for a patient's recovery.
I will remember that I do not treat a fever chart, a cancerous growth, but a sick human being, whose illness may affect the person's family and economic stability. My responsibility includes these related problems, if I am to care adequately for the sick.
I will prevent disease whenever I can,
for prevention is preferable to cure."
Hold your doctors to these words. I triple dog dare you. If you can't, don't be complacent. Your health is your life. If your doctor holds your health hostage for profits (ie. medicine, birth control pills, etc.), then this is a malicious intent to take your life hostage. I've seen patients walk into the doctors' office with bags of pills. Not just one or two, entire bags full of pill bottles. We need medication to get us through a sickness, but if there's a cure then that cure needs to happen.
By your own effortsWaken yourself, watch yourself.And live joyfully.You are the master. ~ Buddha♥ Namaste ♥
It is a general situation that with the deficiency of these Natural bovine supplements
ReplyDelete, that the body becomes weak and hormones work very slow to regulate the body movements.