November 7th, 2014 Total cholesterol = 181 LDL Calc = 90
I think that 20 points went down with Niacin and beet sugar. The rest I could swear is the Riboflavin uptake in the cells (with glucose). I did not one statin. High insulin causes LDL spikes...my intuition was onto something.
Hexosamine biosynthesis impairs insulin action via a cholesterolgenic response.
Plasma membrane cholesterol accumulation has been implicated in cellular insulin resistance. Given the role of the hexosamine biosynthesis pathway (HBP) as a sensor of nutrient excess, coupled to its involvement in the development of insulin resistance, we delineated whether excess glucose flux through this pathway provokes a cholesterolgenic response induced by hyperinsulinemia.
EXPOSING 3T3-L1 ADIPOCYTES TO PHYSIOLOGICALLY RELEVANT DOSES OF HYPERINSULINEMIA (250PM-5000PM) INDUCED A DOSE-DEPENDENT GAIN IN THE MRNA/PROTEIN LEVELS OF 3-HYDROXY-3-METHYL-GLUTARYL-COENZYME A REDUCTASE (HMGR). THESE ELEVATIONS WERE ASSOCIATED WITH ELEVATED PLASMA MEMBRANE CHOLESTEROL.
Mechanistically, hyperinsulinemia increased glucose flux through the HBP and O-linked β-N-acetylglucosamine (O-GlcNAc) modification of specificity protein 1 (Sp1), known to activate cholesterolgenic gene products such as the sterol response element-binding protein (SREBP1) and HMGR. Chromatin immunoprecipitation demonstrated that increased O-GlcNAc modification of Sp1 resulted in a higher binding affinity of Sp1 to the promoter regions of SREBP1 and HMGR. Luciferase assays confirmed that HMGR promoter activity was elevated under these conditions and that inhibition of the HBP with 6-diazo-5-oxo-l-norleucine (DON) prevented hyperinsulinemia-induced activation of the HMGR promoter. In addition, both DON and the Sp1 DNA-binding inhibitor mithramycin prevented the hyperinsulinemia-induced increases in HMGR mRNA/protein and plasma membrane cholesterol. In these mithramycin-treated cells, both cortical filamentous actin structure and insulin-stimulated glucose transport were restored. Together, these data suggest a novel mechanism whereby increased HBP activity increases Sp1 transcriptional activation of a cholesterolgenic program, thereby elevating plasma membrane cholesterol and compromising cytoskeletal structure essential for insulin action.http://www.ncbi.nlm.nih.gov/pubmed/23315940
Remember how Harvard and some goof from Cleveland did a report on how carnitine causes heart disease?
http://www.health.harvard.edu/blog/new-study-links-l-carnitine-in-red-meat-to-heart-disease-201304176083
I've been taking carnitine everyday for a few years which cured my endometriosis. :)
(hint* taurine and leucine pushed up my cholesterol AND my weight. And running and cardiovascuar exercise drops glucose levels - ref: VO2max. I take dextrose with my B2 that helps it's absorbption, not shown here are my glucose levels which is 81). I've also used hot peppers with garlic, (vitamin c & selenium), dextrose to get my body to absorb B2, b12 ZINC, Calcium- lysine (which is also supposed to push up cholesterol) ---
Iodine and tyrosine didn't drop my LDL levels, but the levels didn't go up when I took them.
Here are other things I've consumed: coffee. Chocolate. Apples, Cucumbers, red onions, green onions, peppers, garlic, Salsa Verde from Chipotle, pico de gallo, almond milk, lemons, galaxy peaches, blueberries, powerbars (the chewy kind), balance bars-chocolate cookie dough, almonds, rice cakes, Rice Chex, sticky white rice, nori, carrots, italian pasta sauce, potato starch, mushrooms, ginger, citrus, Sriracha garlic chili sauce, pasta....carnitine, niacin (IN MODERATION- what's in your food might be enough) Vitamin B12, B2, C, ZINC, IODINE, TYROSINE, BENFOTIAMINE (for migraines), lysine, calcium triphosphate (Lil Critters Vegetarian formula with D and phosphate sold at Trader Joes), Calcium carbonate- yes I need my antacids if my stomach acts up. .
Here are the things I've avoided: high fructose corn syrup, dairy (rbgh), leucine, taurine- a lot of oils and fats. I'm not the experts at them, I know that you can drop cholesterol without the omega 3 to 6 business or coconut oil- I think these things are gimmicks. I didn't bother with probiotics. I just worked on my immune system by just using vitamins and exercise.
Let's say it altogether now:
BRISTOL MYERS SQUIBB IS MY B*!
PFIZER IS MY B*!
ASTROZENICA IS MY B*!
Unlike what the doctors and the PA's say, this isn't the cause of my pain. They were just trying to push $140/bottle statins on me.
Then the doctors/PAs find something else to blame me for. They're wrong. It's not my fault, I am innocent. :)
And I just proved it.
The PA I saw yesterday wanted to push spirolactone on me (which I don't need?) for IBS (which it causes) like the metformin for the "prediabetes" that caused PCOS which is caused by high insulin. On Nov. 7th, my glucose was at 81.
So much for a fucking victory. Bitter assholes who mugged me and the insurance and fixed nothing. This is exactly why Obamacare and all the money and politics in the world isn't going to solve anything when ethics are violated.
Several years ago, a team lead came down with brain cancer and passed on. He got on my case for being a "health nut"- he was doing everything right and he passed on.
The moral of the story is that the punishment does not fit the crime?
IT'S NOT YOUR FAULT.
And that hyperjudgemental people are worthless and useless and have no business being relevant whatsoever.
But noooo. Gotta put people down because they need to feel in control of something and they'd stoop so low to blame the victim just to get that feeling. It's pitiful- society's mentality is sad. Its' 2014 already, get a grip? Doctors, family, acquaintances, etc.
IF YOU'RE NOT PART OF THE ANSWER- ***GET OUT OF THE WAY!!!***
Speaking of which..... NEXT BLOG: the Manifesto.
