Tuesday, March 29, 2011

Cramps, Prostaglandins, INFLAMMATION, the cellular biology behind it and nutritional help. This info is MONEY!


Both Endometriosis and Poly-cystic Ovarian Syndrome are caused by Estrogen Dominance.
This page demonstrates why insulin resistance is only part of the problem. Not the problem.

Note: cutting sugar will only help you feel better. It will not cure estrogen dominance. You need to cut out transfats (IN PROCESSED FOODS), eat omega 3's, Vitamin B's, and bromelain (enzyme in pineapples).

Like previously mentioned, cutting out sugar isn't enough.

THIS IS A MUST READ. For every woman regardless if you have PCOS/Endometriosis or not.
http://www.endo-resolved.com/prostaglandins.html
Most of this blog will be notes taken out from this page, this information is money.

I already blogged on the link between inflammation and estrogen dominance.

First of all, without these T-cells, none of these ovarian cysts would happen. (I can't make this up.)
"A study of female mice is suggesting that ovarian cysts may at least partially be the result of an immune system dysfunction. The gland involved is the thymus gland, which is responsible for the management of major aspects of your immune system. One of the functions of the thymus gland is to produce T-cells, which are white blood cells that help protect you from infection and also perform other important activities.
The researchers reported that ovarian cysts in the female mice did not develop unless there was an absence of regulatory T-cells."
http://www.ovarian-cysts-pcos.com/news81.html
The cellular biology is complex but this is incredibly good research. Diet is our only defense against it at this time, however if Big Pharma figures out how to combat the cause of inflammation, their products will be demand inelastic. It may be a bigger hit than a cancer cure.
Inflammatory issues and auto-immune disease are not limited to PCOS, inflammation also contributes to things like allergies (think about those sinuses) and celiac disease which is very common in women with PCOS.
NOTES:

PROSTAGLANDINS

Prostaglandins are like hormones in that they act as chemical messengers, but they do not move to other places in the body. They work right within the cells where they are made.

- any of a group of about a dozen compounds synthesised from fatty acids in mammals as well as in lower animals. Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue. Different prostaglandins have been found to raise or lower blood pressure and regulate smooth muscle activity and glandular secretions. One such substance, which stimulates contraction of the uterus, is used clinically to induce labour; another has been in experimental use as a birth control agent. Prostaglandins also control the substances involved in the transmission of nerve impulses, participate in the body’s defences against infection, and regulate the rate of metabolism in various tissues.

Several prostaglandins have been shown to induce fever, possibly by participating in the temperature-regulating mechanisms in the hypothalamus; they also play a part in inflammation. Many naturally occurring prostaglandins as well as many artificial forms have been synthesised in the laboratory

Chemical Messengers


Prostaglandins vary somewhat from one another based upon subtle differences in their chemical structures. These small variations are believed to be responsible for the immense diversity of effects they have on the body. In general, prostaglandins act in a manner similar to that of hormones, by stimulating target cells into action. However, they differ from hormones in that they act locally, near their site of synthesis, and they are metabolised very rapidly. Interestingly, thesame prostaglandins act differently in different tissue. (The in-built intelligence of the human body, that we will never understand)!


FUNCTION OF PROSTAGLANDINS

- Activation of the inflammatory responses at the sites of damaged tissue, and production of pain and fever. When tissues are damaged, white blood cells flood the site to try to minimise tissue destruction. Prostaglandins are produced as a result.

- Blood clots form when a blood vessel is damaged. A type of prostaglandin called thromboxane stimulates constriction and clotting of platelets. Also the opposite happens and protastaglandin 12 (PG12) is produced on the walls of blood vessels where clots should not be forming. ( The body is very, very clever. It knows what to do, where to do it and when.)
(Does anyone have Factor 2 or Factor 5 type blood? This might be WHY!)
- Certain prostaglandins are involved with the introduction of labour and other reproductive processes, and the role of fertility. PGE2 causes uterine contractions and has been used to induce labour.

- Prostaglandins are involved in several other organs and systems such as the gastrointestinal tract, cell growth and the immune system response.
  • Prostaglandins are a subset of a larger family of substances called eicosanoids
  • Other subgroups include thromboxanes, leukotrienes and lipoxins (just out of interest!)
  • Eicosanoids are localised tissue hormones that seem to be the fundamental regulating molecules in most forms of life
  • Prostaglandins are chemical mediators, or ‘local’ hormones. Whereas hormones circulate in the blood stream to influence distant tissues, prostaglandins act locally on adjacent cells
  • Prostaglandins serve as a catalyst for a large number of processes including -the movement of calcium and other substances into and out of cells (it's said that calcium and Vitamin D helps the uterus with contractions, Notice the mention of control of insulin release and elimination of bad free radicals in this source. Free Radicals contribute to inflammation.) -dilation and contraction -inhibition and promotion of blood clotting -regulation of secretions including digestive juices and hormones -control of fertility -cell division -growth
  • Prostaglandins are produced in the cells by the action of enzymes on essential fatty-acid

    • THE SERIES 1 and SERIES 2 PROSTAGLANDINS

    Series 1 prostaglandins have the opposite effect of the Series 2 prostaglandins. Series 1 reduce inflammation, dilate blood vessels, and inhibit blood clotting. The strong anti-inflammatory properties help the body recover from injury by reducing pain, swelling and redness.
    -Beneficial prostaglandins are made from a fatty acid found mostly in marine plants and fish known as EPA (eicosapentaenoic acid)
    -EPA is the most important member of an exclusive group of three fatty acids called the "omega-3 fatty acids"
    -OMEGA-3 FATTY ACIDS - includes alpha linoleic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)

    Series 2 prostaglandins play a role in swelling and inflammation at sites of damage or injury. They also play a role in inducing birth, in regulating temperature, lowering blood pressure, and in the regulation of platelet forming and clotting. The role of Series 2 Prostaglandins does serve a vital role for the body for without it you would bleed to death from the slightest cut. However, in excess, these prostaglandins are harmful and many diseases are directly linked to excessive inflammation and blood clotting. The Series 2 group is involved in intense actions, often in response to some emergency such as injury or stress. The Series 3 group has a modulating effect.

    The Series 3 prostaglandins are formed at a slower rate and work to deal with excessive Series 2 prostaglandin production.

    ‘Antagonistic Prostaglandins’ - in simple terms this means unfriendly prostaglandins.

    Antagonistic prostaglandins are made from a fatty acid called arachidonic acid.
    Aracidonic acid is obtained from animal products - meat and dairy.
    Arachidonic acid can also be made from another fatty acid linoleic acid, through the animal food chain consumption
    Linoleic acid is a fatty acid found in plant oils, such as corn oil, soybean oil, and other light vegetable oils. We also obtain linoleic acid from meat and dairy products (because the animals eat plants and store Linoleic acid)

    Alpha Linoleic Acid (ALA)
    -on ALA-it's made in the chloroplasts of green plants from linoleic acid.
    -In mammals, linoleic acid is converted to arachidonic acid that is used to make the antagonistic prostaglandins.
    -BUT, in the green plant the same linoleic acid is converted into the beneficial ALA
    -ALA is important because it serves as the building material for EPA

    Eicosapentaenoic Acid (EPA)
    -EPA is the most critical of the omega 3 fatty acids. It is the only material that our bodies use to make the beneficial prostaglandins that help reduce inflammation

    Docosahexaenoic Acid (DHA)
    -DHA is another omega 3 fatty acid. It is an integral part of eye and brain tissue.
    -It is made by marine algae, plankton, fish and mammals from EPA. Fish accumulate DHA in their oily tissue, along with EPA

    Oleic Acid (EFA)
    -found chiefly in olive oil and nuts
    -will inhibit the prostaglandin pathway. But the block being set up is one which will inhibit the Series 2 prostaglandins (the ones which cause inflammation and swelling).

    -Which is why women with endometriosis are advised to change the oil in their diet to only include the oils which will block Series 2.
    • Evening Primrose Oil
    • Fish Oils
    • Flax seed oil
    • Borage oil
    ASPRIN- a non-steroidal anti-inflammatory, was discovered over 100 years ago.
    It works by blocking prostaglandins that are produced in inflamed or injured tissues and cause the sensation of pain. It also acts centrally: the salicylate and acetate parts of aspirin's chemical structure (aspirin is acetyl salicylic acid) cross separately into the brain and spinal cord. There they act on prostaglandins in sites in the central nervous system known to be involved in both the perception and transmission of pain.

    Prostaglandins are released by the endometrium during the menstrual cycle. Some women release more prostaglandin during menstruation than other women. These higher levels of prostaglandins in women with severe dysmenorrhea (painful periods) results in increased uterine contractions and muscular spasm.

    "I define an activated essential fatty acid as any essential fatty acid that has this new double bond inserted by the delta-6-desaturase enzyme. This is because this new double bond starts bending the essential fatty acid to get the appropriate spatial configuration required to make an eicosanoid. Once this new double bond has been inserted into a short-chain essential fatty acid, then very small amounts of these activated essential fatty acids can profoundly affect eicosanoid balance in your body.

    However, there are many factors that can decrease the activity of delta-6-desaturase enzyme. The most important factor is age itself. There are two times in your life during which this enzyme is relatively inactive. The first is at birth. For the first six months of life, the activity of this key enzyme in the newborn is relatively low. But this is also the time at which maximum amounts of long-chain essential fatty acids are required by the child since the brain is growing at the fastest possible rate, and these long-chain essential fatty acids are the key structural building blocks for the brain. Nature has developed a unique solution to this problem: mother's breast milk. Breast milk is very rich in GLA and other long-chain essential fatty acids such as the EPA and DHA. By supplying these activated essential fatty acids through the diet, this early inactivity of the delta-6-desaturase enzyme is overcome.

    The second time in your life during which the activity of this enzyme begins to decrease is after the age of 30. Eicosanoids are critical for successful reproduction. Since the primary child-bearing years for women are between the ages of 18 and 30, it makes good evolutionary sense to start turning down the activity of a key enzyme needed to make the precursors of eicosanoids required for fertility after age 30.

    The delta-6-desaturase enzyme can also be inhibited by viral infection. The only known anti-viral agents are "good" eicosanoids such as PGA1 because of their ability to increase cyclic AMP levels that keep viral replication under control. On the other hand, if you are a virus, then your number-one goal is to inhibit the formation of this type of eicosanoid. This is exactly what many viruses do by inhibiting the delta-6-desaturase enzyme. By doing so, the virus has devised an incredibly clever way to circumvent the body's primary anti-viral drug (i.e. PGA1).

    The final factor that can decrease the activity of delta-6-desaturase is the presence of two types of fatty acids in your diet; trans fats and Omega-3 fats. Trans fatty acids don't exist naturally but are produced by food manufacturers. They are essential Omega-6 fatty acids that have been transformed by a commercial process (known as hydrogenation) into a new spatial configuration that is more stable to prevent oxidation.
    The increased stability of these fatty acids makes them ideal for processed foods, but also makes trans fatty acids strong inhibitors of the delta-6-desaturase enzyme. Trans fatty acids occupy the active site of the delta-6-desaturase enzyme, thus preventing the formation of the activated essential fatty acids required for eicosanoid synthesis. In essence, trans fatty acids can be viewed as anti-essential fatty acids because of their inhibition of eicosanoid synthesis. This may be the reason why they are strongly implicated in the development of heart disease. How do you know if a food product you're consuming contains trans fatty acids?.....

    "It wasn't that insulin was a cause, but that it drove the metabolism of essential fatty acids to make more arachidonic acid, and therefore more "bad" eicosanoids. The more "bad" eicosanoids you make, the more likely you will promote platelet aggregation and increased vasoconstriction, the underlying factors for a heart attack."
    "

    AGAIN EVIDENCE. METFORMIN WILL NOT CURE ESTROGEN DOMINANCE OR PCOS.

    BACK TO THE ORIGIONAL ARTICLE:

    Prostaglandins and inflammation


    Prostaglandins are known as local hormones - they are released from cells and bring about changes in neighbouring cells that carry specific prostaglandin receptors in their membranes.

    The influence which prostaglandins have depends upon the type of tissue they are acting upon. Such action may be direct, or as a result of modifying the actions of other signalling molecules.

    As well as signalling and influencing pain messengers to the brain, prostaglandins will interact with other chemicals in the body when there is damage. They will also intensify the effects of other chemical mediators such as histamine.

    Acting in concert these substances can bring about vasodilatation and an increase in the permeability of capillaries supplying the damaged area, encouraging the migration of phagocytes (Phagocytes are leukocytes - white blood cells - that engulf invading micro-organisms, and then kill them. They are part of our natural defence against infection ) from the blood through capillary walls into the damaged tissue. As a result of these changes, the blood supply to the area increases, the tissues swell, causing inflammation and pain subsequently occurs.


    Phagocytes in more detail


    Phagocytes are large white cells that can engulf and digest foreign invaders.They include monocytes, which circulate in the blood, and macrophages, which are found in tissues throughout the body, as well as neutrophils, cells that circulate in the blood but move into tissues where they are needed. Macrophages are versatile cells; they act as scavengers, they secrete a wide variety of powerful chemicals, and they play an essential role in activating T cells (part of your immune system).

    Neutrophils are not only phagocytes but also granulocytes: they contain granules filled with potent chemicals. These chemicals, in addition to destroying micro-organisms, play a key role in acute inflammatory reactions.


    There are two main types of phagocytes: neutrophills and macrophages.


    Neutrophils:
    • Are made in bone marrow throughout life.
    • Make up 60% of white blood cells.
    • Travel through the blood.
    • Are short lived.
    • Squeeze through capillary walls to patrol tissue.
    • Released in large numbers during infection.
    • Dead neutrophils make pus.


    Macrophages:
    • Are made in bone marrow throughout life.
    • Leave bone marrow and travel in blood as monocytes.
    • Are longer lived than neutrophils.
    • Are found in organs such as: lungs, liver, kidney, spleen, lymph nodes.



    Prostaglandins and womb contractions


    Primary dysmenorrhoea (painful periods) is caused by cramping in the uterine muscles — the uterus is a muscle and like all muscles it contracts and relaxes! Women don’t usually feel these muscles contract, unless it is a particularly strong contraction. With endometriosis the pain associated with menstrual cramps is usually very intense and painful. During a contraction, blood supply to the uterus can be temporarily cut off. This deprives the muscle of oxygen, which causes pain. But why do the uterine muscles contract?

    It is caused by the series two prostaglandins. Series two prostaglandins help the uterus to shed the womb lining during menstruation by causing the contraction of the uterine muscles. Understandably, if too many of these prostaglandins are produced, then the contractions will be more severe and cause painful menstrual cramps — primary dysmenorrhoea.

    However, not all prostaglandins have this effect on the involuntary uterine muscles, which is why diet can play a big role in minimising the production of series two prostaglandins. The types of fatty acids included in your diet influence the types of prostaglandins made. For example, series two prostaglandin (the type that trigger powerful contractions of the uterus) levels are increased when animal fat is included in the diet. In contrast, series one and series three prostaglandins (the type that don’t cause uterine contractions) are produced when the diet is higher in linoleic acid, which is found naturally in tuna and salmon oil. Evening primrose oil and starflower oil are also rich sources of linoleic acid, which is why they are often recommended for women suffering from period cramps and are especially helpful for women with endometriosis.


    Prostaglandins and infertility


    I have to pause right there. This is incredibly good information so far. Now we know that both PCOS and Endometriosis are both caused by Estrogen Dominance?

    The progtaglandins' relationship with Progesterone is where it gets interesting.
    We have concluded that the progressive decline in prostaglandin production and the rise in progesterone output from luteinizing human granulosa cells occur independently of each other.

    It was concluded that the co-operation of progesterone in the earlier stage and of prostaglandins in the later stage of the preovulatory interval is required to mediate the action of hCG on ovulation.
    hCG on ovulation. Oh my god!!! That's the release of the egg!
    That's fertility in Layman's terms.



    That's a pleasant surprise. I'm not ready for a baby yet.

    This study cites the excessive progtaglandins in endo patients who cannot conceive.

    This is Greek to me.
    "Based on our data and that of others, we
    hypothesize that these cAMP analogues act downstream of the
    EP2 receptor. Thus, in addition to a direct effect of GDF-9 on
    the synthesis of hyaluronan synthase 2, GDF-9 appears to
    stimulate a Cox2yPGE2yEP2 pathway which in vivo is required
    for optimal cumulus expansion. Furthermore, induction of this
    same Cox2yPGE2yEP2 pathway by GDF-9 is also apparently
    important for progesterone synthesis by the cumulus granulosa
    cells. Thus, at least two major functions of PGE2 signaling
    through EP2 in the periovulatory follicle appear to be enhancement of cumulus expansion and production of progesterone,
    both of which are necessary for efficient delivery of oocytes into
    the oviduct, maintenance of oocyte function, and fertilization.
    Further studies are needed to determine which genes in the
    progesterone synthetic pathway are directly induced by PGE2,
    whether StAR mRNA is stimulated indirectly by GDF-9 via
    induction of the EP2 pathway, and which genes or gene products
    in addition to Cox2 and EP2 are regulated by GDF-9 in this
    process."

    BACK TO THE ARTICLE:

    "One major group of hormones secreted by the normal endometrium is that of prostaglandins. Prostaglandins are required for many bodily processes, including several stages of the menstrual cycle and pregnancy.

    Prostaglandins are required for ovulation, regression of the corpus luteum (i.e., ending the monthly menstrual cycle), sperm motility, immune interaction, contraction of the uterus at birth and menstrual cramps. Endometrial implants and the endometrium of the uterus are the richest source of prostaglandin production in the body.

    However, the problem with endometrial implants includes:

    - Prostaglandins are released into the abdomen instead of inside the womb
    - Prostaglandins release by the implants seem to be out of phase with their release by the uterus
    - Prostaglandins are produced at the wrong time sending the wrong message


    For instance, there is a normal surge in prostaglandin F production at the end of the menstrual cycle, causing the effect of the corpus luteum of the ovary to die down and signalling the start of a new menstrual cycle. The implants of endometriosis produce their own prostaglandin surge several days after that of the womb lining. This may be one of the main causes of very early miscarriage.

    If a women is a few days pregnant then the endometriosis implants producing prostaglandin F would incorrectly signal the ovary to start a new menstrual cycle, causing the womb lining with the implanted egg to be expelled - and the consequence is an early miscarriage.

    Prostaglandins also play an important role in the contractions of womb and fallopian tubes. During the normal menstrual cycle, the gentle contraction of the womb and fallopian tube aids the movement of egg and sperm to the outer third of the fallopian tube where fertilisation occurs. High concentrations of endometriosis implants may prevent fertilisation. An excess of PGF2 and PGE2 could cause contractions that are too strong and expel the egg too quickly.


    Prostglandins and Diet


    You should all have had it ‘drummed into you’ by now that the KEY way to shift the production of prostaglandins from the negative (inflammatory / pain messenger / womb contracting type) to the positive (anti-inflammatory / suppress womb contractions and pain messenger type), is through your diet, and most crucially by the types of fats and oils you include in your diet.

    Several enzymes take part in the process that transforms fats into prostaglandins. These enzymes act as gatekeepers, channelling fats into the making of different prostaglandins. Like other enzymes in the body, they require specific nutrient coenzymes to do their job.

    The enzyme delta-6-desaturase acts on linoleic acid - from most vegetable, nut and seed oils - to transform it to gamma-linoleic acid (GLA). GLA is used to make the anti-inflammatory series 1 prostaglandins and also supports healthy nervous system function.

    The activity of delta-6-desaturase is affected by dietary factors. Trans-fatty acids from hydrogenated oils, too much saturated fat (found in meats, fried foods, junk foods and dairy products) in the diet, high stress, too much sugar or refined flours in the diet all slow down this enzyme down.


    Trans-fatty Acids


    Many processed foods contain trans-fatty acids. These fats slow down the activity of delta-6-desaturase. They are manufactured from vegetable oils in a process called hydrogenation, which involves the bombardment of liquid oils with hydrogen atoms to make them solid and prevent them going rancid.
    These trans-fats have harmful effects on the stability of cell membranes and the structure of nerve and brain cells. They also interfere with the formation of anti-inflammatory prostglandins.


    B Vitamins


    The B vitamins are crucial for the conversion of linoleic acid to GLA, which is necessary to produce beneficial prostaglandins. Linoleic acid is an essential fatty acid (EFA), and it is found in foods such as fresh nuts and seeds, safflower oil, and Evening Primrose Oil.

    The B vitamins are required to convert this essential oil into a form that can be used by the body to produce the good prostaglandins.


    Bromelain and prostaglandins


    The enzyme bromelain from the stem of the pineapple, is also effective in inhibiting the inflammatory prostaglandins. In an extensive five-year study of more than 200 people experiencing inflammation as a result of surgery, traumatic injuries and wounds, 75 percent of the study participants had good to excellent improvement with bromelain; a much higher rate than that afforded by drugs. Most of the people in this study were discharged from the hospital in only eight days—half the usual amount of time. They also experienced no side effects.


    To conclude ….


    Along with hormones, these are very powerful and complex substances and can be easily influenced by outside factors through diet. It could be that our emotions as well as stress could alter and influence the way these natural bodily chemicals work. Many of us have felt and witnessed the changes in our hormones brought about by stress and emotions.

    ‘You are what you eat’ - we have all heard that phrase. Our bodies react to what we eat. It sometimes seems incredible that the body can differentiate between the chemical and molecular structure of 2 different oils (its only food!) - but our bodies are very clever and NOTHING goes unnoticed. It may not show up immediately, but if you feed your body with things it does not like or need, eventually you will get signals.

    Fortunately, due to huge advances in understanding the body and how it works, we now have a better awareness how correct diet is crucial to the health of the body. And women with endometriosis can take advantage of the discoveries and knowledge about the role of diet in controlling their symptoms and shifting the levels of prostaglandins from the bad ones to the good ones.

    As it is mentioned above - we do need prostaglandins - both types - they are all part of the complex and intricate orchestra of the body. But it does seem apparent from research that women with endometriosis are producing too many of the negative prostaglandins, which is the cause of many symptoms.

    If you take these findings on board then you are part way to taking control of this disease, rather than IT taking control of you."



    Acronyms

    AA

    Arachidonic acid

    COX

    Cyclooxygenase

    DHET

    Dihydroxyeicosatrienoic acid

    EET

    Epoxyeicosatrienoic acid

    HETE

    Hydroxyeicosatetraenoic acid

    HPETE

    Hydroxyperoxyeicosatetraenoic acid

    LTB, LTC

    Leukotriene B, C, etc

    LOX

    Lipoxygenase

    LXA, LXB

    Lipoxin A, B

    NSAID

    Nonsteroidal anti-inflammatory drug

    PGE, PGF

    Prostaglandin E, F, etc

    PLA, PLC

    Phospholipase A, C

    TXA, TXB

    Thromboxane A, B

    "REPRODUCTIVE ORGANS

    Female Reproductive Organs

    "Animal studies demonstrate a role for Prostaglandin E2 and Prostaglandin F2 in early reproductive processes such as ovulation, luteolysis, and fertilization. Uterine muscle is contracted by Prostaglandin F2, ThromboxaneA2, and low concentrations of Prostaglandin E2; PGI2 and high concentrations of Prostaglandin E2 cause relaxation. Prostaglandin

    F2, together with oxytocin, is essential for the onset of parturition. The effects of prostaglandins on uterine function are discussed below (see Clinical Pharmacology of Eicosanoids)."


    http://basic-clinical-pharmacology.net/chapter%2018_%20the%20eicosanoids%20prostaglandins,%20thromboxanes,%20leukotrienes,%20&%20related%20compounds.htm
    Posted by at 5 comments:
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    Sunday, March 27, 2011

    THE SICK CULT OF METFORMIN WORSHIP.


    Update: today is 9/28/2014  THIS US OF PUBLIC RELATION TOOLS ALREADY VIOLATES HIPPOCRATIC OATH AND AMA CODE OF ETHICS. 
    Health Impact News Editor Glenn Greenwald, a journalist, constitutional lawyer, commentator, and author of three New York Times best-selling books on politics and law, has been working with NBC News in publishing a series of articles on how covert government agents infiltrate the Internet to “manipulate, deceive, and destroy reputations.”
    The information is based on documents leaked by National Security Agency (NSA) whistleblower Edward Snowden. Greenwald’s article, How Covert Agents Infiltrate the Internet to Manipulate, Deceive, and Destroy Reputations, is based on four classified documents produced by the British spy agency GCHQ, and presented to the NSA and three other English speaking agencies reportedly part of “The Five Eyes Alliance.”
    In this shocking piece, Greenwald publishes a copy of a spy training manual used entitled: “The Art of Deception: Training for Online Covert Operations.” Greenwald writes that agencies like the NSA are “attempting to control, infiltrate, manipulate, and warp online discourse, and in doing so, are compromising the integrity of the internet itself.” Greenwald writes:
    Among the core self-identified purposes of JTRIG are two tactics: (1) to inject all sorts of false material onto the internet in order to destroy the reputation of its targets; and (2)to use social sciences and other techniques to manipulate online discourse and activism to generate outcomes it considers desirable. To see how extremist these programs are, just consider the tactics they boast of using to achieve those ends: “false flag operations” (posting material to the internet and falsely attributing it to someone else), fake victim blog posts (pretending to be a victim of the individual whose reputation they want to destroy), and posting “negative information” on various forums.
    While this kind of counter-intelligence activity may not sound surprising given the objectives of spy agencies going after terrorists, what disturbs Greenwald (and many others) is that the discussion regarding these techniques have been greatly expanded to include the general public:
    Critically, the “targets” for this deceit and reputation-destruction extend far beyond the customary roster of normal spycraft: hostile nations and their leaders, military agencies, and intelligence services. In fact, the discussion of many of these techniques occurs in the context of using them in lieu of “traditional law enforcement” against people suspected (but not charged or convicted) of ordinary crimes or, more broadly still, “hacktivism”, meaning those who use online protest activity for political ends.
    The title page of one of these documents reflects the agency’s own awareness that it is “pushing the boundaries” by using “cyber offensive” techniques against people who havenothing to do with terrorism or national security threats, and indeed, centrally involves law enforcement agents who investigate ordinary crimes.
    No matter your views on Anonymous, “hacktivists” or garden-variety criminals, it is not difficult to see how dangerous it is to have secret government agencies being able to target any individuals they want – who have never been charged with, let alone convicted of, any crimes – with these sorts of online, deception-based tactics of reputation destruction and disruption.
    And while these leaked documents concern the British spy agency, Greenwald is quick to point out that the Obama administration has actually been open and forward about using such techniques in the U.S.:
    Government plans to monitor and influence internet communications, and covertly infiltrate online communities in order to sow dissension and disseminate false information, have long been the source of speculation. Harvard Law Professor Cass Sunstein, a close Obama adviser and the White House’s former head of the Office of Information and Regulatory Affairs, wrote a controversial paper in 2008 proposing that the US government employ teams of covert agents and pseudo-”independent” advocates to “cognitively infiltrate” online groups and websites, as well as other activist groups.
    Sunstein also proposed sending covert agents into “chat rooms, online social networks, or even real-space groups” which spread what he views as false and damaging “conspiracy theories” about the government. Ironically, the very same Sunstein was recently named by Obama to serve as a member of the NSA review panel created by the White House, one that – while disputing key NSA claims – proceeded to propose many cosmetic reforms to the agency’s powers (most of which were ignored by the President who appointed them).
    Today, the pharmaceutical industry is practically a branch of the government. The government awards grants from your tax dollars to research new vaccines, the FDA approves them, and then government organizations like the CDC and UNICEF purchase the vaccines with your tax dollars. The CDC even holds patents and earns royalties on vaccines, and many of the top scientists work for both the government and the pharmaceutical companies. Julie Gerberding, for example, was the head of the CDC from 2002 to 2009, and then took over as head of the pharmaceutical company Merck’s vaccine division overseeing billions of dollars in sales. The government definitely has a vested interest in protecting the vaccine market.
    Use emotional warfare on anti-vax blogs. Tell emotional stories full of tears and sobbing and unbearable grief and terror, about people in your own family or people you read about, who were sick with or died of terrible diseases. Don’t hold back details about bodily fluids and suchlike: the more gross the better. This stuff has a way of infiltrating the minds of readers and subtly influencing their decisions, in a manner similar to advertising.’‘Go in there and “agree with them” and then say things that appear thoroughly delusional, overtly nuts, blatantly and obviously wrong even to nincompoops, etc. Occasional spelling and grammar errors are also useful but don’t over-do. The point of this exercise is to create an impression that drives away undecideds who may come in to check out these sites. It helps to do this as a group effort and begin gradually, so the sites appear to be “going downhill slowly.”‘
    As far as social media, the social media company might provide the platform, but you still own the content. You are under no obligation to allow trolls and others to voice their contrary opinions on your content just because it is published on the Internet. People are free to publish their own content in their own space – they have no right to do it in yours.
    Of course the owner of the social media platform might engage in their own form of censorship or restrictions, but that is a topic of another article to follow. For now, if you are a publisher of content on the Internet today (as almost everyone is), just be aware that as you grow in popularity, you may very well start attracting trolls trying to discredit you or your message. Be aware of their tactics, and take action accordingly to protect your freedom of speech.
    http://healthimpactnews.com/2014/internet-trolls-may-be-trained-government-agents-according-to-leaked-document/


    Update: today is 9/11/2014
    Now everyone is being told they're diabetic.

    The 42-year-old information technology worker’s name recently showed up in a database of millions of people with “diabetes interest” sold by Acxiom Corp., one of the world’s biggest data brokers. One buyer, data reseller Exact Data, posted Abate’s name and address online, along with 100 others, under the header Sample Diabetes Mailing List. It’s just one of hundreds of medical databases up for sale to marketers......The lists typically sell for about 15 cents per name and can be broken down into sub-categories, like ethnicity, income level and geography for a few pennies more.  http://www.bloomberg.com/news/2014-09-11/how-big-data-peers-inside-your-medicine-chest.html
    There's something FISHY about Metformin. No seriously, it smells like dead fish.

    The added trouble to having PCOS is being pimped out to big pharma.

    CLEARING UP THE INSULIN RESISTANCE MYTH:
    - Estrogen dominance CAUSES Insulin Resistance. Insulin resistance is a symptom of estrogen dominance. They lied about the *cause and effect* order of this syndrome and I will prove this.

    On cyberspace.

    How?

    By telling the truth. The trick to a debate is to win the audience, not to beat the opposition. And telling the truth is the best way to do it. I'm not laying my character critisms on the Facebook pages, that's why I'm elaborating them here. I've had more than ample experience debating realtor parasites and political hacks. A bunch of inaccurate, even manipulative b*tches who are trying to exploit your illness is actually kind of easy?

    I like to settle the score with facts. Facts help the patients recover. It's troubling enough that the medical bureaucracy is stifling effective treatment/cure for PCOS as it is. Then you have to suffer these people.




    "It wasn't that insulin was a cause, but that it drove the metabolism of essential fatty acids to make more arachidonic acid, and therefore more "bad" eicosanoids. The more "bad" eicosanoids you make, the more likely you will promote platelet aggregation and increased vasoconstriction, the underlying factors for a heart attack."

    PCOS is an endocrine INFLAMMATORY issue. My glucose was 86 when my last cyst ruptured. It is not caused by insulin resistance. I promise.
    Let's start out by defining INSULIN RESISTANCE. It's also known as "Metabolic syndrome".

    "Symptoms

    • Extra weight around your waist (central or abdominal obesity)

    Signs and tests

    According to the American Heart Association and the National Heart, Lung, and Blood Institute, metabolic syndrome is present if you have three or more of the following signs:
    • Blood pressure equal to or higher than 130/85 mmHg
    • Fasting blood sugar (glucose) equal to or higher than 100 mg/dL
    • Large waist circumference (length around the waist):
      • Men - 40 inches or more
      • Women - 35 inches or more
    • Low HDL cholesterol:
      • Men - under 40 mg/dL
      • Women - under 50 mg/dL
    • Triglycerides equal to or higher than 150 mg/dL"http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004546/
    Now here are my levels. My BMI was 19 at the time.


    Let's see,
    -my HDL was 57, above 50 guideline for Insulin Resistance.
    -My weight was 110 at the time and I'm 5'2, my waist was much smaller than 35 inches on the Insulin Resistance guidelines for diagnosis.
    -My fasting blood sugar (glucose) was 94... it was lower than the 100 mg/dL needed to diagnose me for Insulin Resistance diagnosis.
    -My triglycerides were 105, just a little under the 150 guideline required to diagnose anyone with insulin resistance.
    I DID NOT HAVE INSULIN RESISTANCE WITH ESTROGEN DOMINANCE OR THE LAST CYST RUPTURE.

    And I really had an ovarian cyst rupture. Why else would I invest so much time in digging up research and interacting with other patients if I didn't have it?

    Here's the scoop. All Metformin does is lower the glucose levels in your blood. That's it! It is not the miracle diet. It is not a fertility treatment nor does it prevent miscarraiges.
    It is not the second coming of Christ.

    The Metformin worship within Metformin shill groups anywhere within any contrived PCOS "community" rivals Obamamania and can be classified as idolatry. Metformin is a false God.


    Everybody already knows that you need to lower your sugar intake. Obviously this isn't enough.


    There are a few sites on Facebook that tackle this. A lot of doctors are pushing Metformin. So are a bunch of internet shills, ON FACEBOOK. The "experts" are still trying to say that insulin resistance causes it? Who the heck am I to contradict the "experts'" opinion? I'm not a doctor getting kickbacks from Bristol-Myers Squibb, I'm just a woman who actually have PCOS and endometriosis (an obvious sign of estrogen dominance) and I really beat insulin resistance. In real life.

    I don't know any of these people in this support group. The only one I like is the Holistic Nutritionalist because she's preaching health, not drugs. I think she's the only ethical one on the board.
    Oh by the way, Metformin does not help women conceive nor does it prevent miscarraiges.
    METFORMIN DOES *NOT* PREVENT MISCARRAIGES!
    "The rates of first-trimester pregnancy loss did not differ significantly among the groups. However, the conception rate among subjects who ovulated was significantly lower in the metformin group (21.7%) than in either the clomiphene group (39.5%, P=0.002) or the combination-therapy group (46.0%, P<0.001)."
    Just a brief comment about fallacies (the Metformin shillery is full of them!)

    The PCOS Metformin shills push a post hoc fallacy by saying, "insulin resistance causes estrogen dominance". This argument twists the cause and effect logic. Estrogen dominance CAUSES insulin resistance, Insulin resistance is the symptom of estrogen dominance"

    A POST HOC FALLACY IS



    "(also called false cause)

    This fallacy gets its name from the Latin phrase "post hoc, ergo propter hoc," which translates as "after this, therefore because of this."



    HERE IS MY EVIDENCE PROVING THAT ESTROGEN DOMINANCE CAUSES INSULIN RESISTANCE:
    "In conclusion, it is demonstrated that excess dietary glycotoxins in experimental animals appeared to be accumulated in the ovarian tissues and are also associated with metabolic and hormonal alterations.”
    http://www.springerlink.com/content/g872k677v1114520/
    Estrogen Dominance causes Insulin Resistance. (High Progesterone levels, esp. in women in their second trimester of pregnancy are at risk for Gestational Diabetes).
    "...at first, makes pancreatic cells secrete the glucose-regulating hormone insulin. Then after repeated exposure of estrogen (produced by our bodies? and xeno estrogens) caused insulin resistance."
    (I already blogged about it here
    http://pcossurvivor.blogspot.com/2011/03/of-estrogen-dominance-pms-migraines.html)
    The other fallacy is "APPEAL TO IGNORANCE"


    Definition: In the appeal to ignorance, the arguer basically says, "Look, there's no conclusive evidence on the issue at hand. Therefore, you should accept my conclusion on this issue." (often the ladies just ignore my post and pretend it wasn't there. It's a common tactic amongst sock puppets and Google Monkies if they're trying to "talk over you")

    On Fallacies

    Now we have an army of contrived, condescending and self righteous b*tches with self esteem issues pushing fallacies.

    Here is Diane Kress who aggressively patronizes everyone on the PCOS board to buy her book Metabolism Miracle. She's a jerk. Her attempt to help diabetics might work, IF you're a diabetic.

    There's a trick to marketing. Marketing is simply bringing the product to the buyers, or the "market". Advertising is just a part of marketing, but you'll only get it if you have a business education. Nobody really cares. The other strategy of marketing/advertising is tricking the buyer into believing that they need your product. And Diane Kress tried to tell me I was a "Met B" diabetic even if my glucose, LDL and triglycerides were far lower than pre-diabetic levels.

    She deleted the conversation we had on her page so I'm very sorry I couldn't take a snapshot to show it here.

    But her marketing skills are clever. Unfortunately, her product (and her personality) won't benefit me.

    She's also quite openly candid in her critism of her "competition". Sara Ouellette is holistic nutritionist who just posts vegitarian recipes. Honestly, I don't mind Sara's advertisements because they're a lot more sufferable and ethical than pushing women with PCOS on Metformin.

    But Diane made a big fuss on Sara's page about putting flaxseeds on kidney beans in a vegetarian recipe. Like, who cares? Flaxseeds on kidney beans in a vegetarian chili is a LOT healthier than prescribing Metformin.

    Diane Kress's fallacies (beside annoying the audience) include 1)a lame attempt at a Straw Man argument and 2)begging the question. (All the Metformin shills "Beg the Question").


    Dude, seriously.

    PCOS sucks enough as it is without the antagonizing bullsh*t from unfriendly vultures and parasites.


    Look at these EXAGGERATED statements.
    (btw, Migraines are caused by a Vitamin B deficiency. See link for evidence.)


    Angel Fain is my new hero.



    Now I can be candid about this because I'm not selling anything. I'm the audience and nobody tried to win me. I don't like these ladies either. I know that PCOS causes symptoms that causes people to feel less attractive (ie. hirutism and obesity). But at the end of the day, no matter how good anyone looks- their personality is going to make or break them.
    This is the link to their group.





    I'm not one that pokes fun at the obese (I know the US has an obesity EPIDEMIC and some people really can't help it). I'm poking fun at @$$holes.

    Typically, in any weight loss advertisement, don't you show a before and after picture of yourself? She doesn't look like a size 18.


    This lady's daughter is 5'2, 105 pounds. Her daughter's PCOS didn't come from insulin resistance. Notice how the moderator doesn't even consider that. They didn't consider my case either when I told them that my glucose was low when my last cyst ruptured. (the point of me being here is to stop the cysts...hello? Metformin obviously won't do that).


    She makes a hasty generalization and she totally misses the point.

    TARA LIES AGAIN.
    "everyone with PCOS has insulin resistance".

    She says this only AFTER I told them REPEATEDLY my cyst ruptured with low glucose levels. I'm surprised at the nerve that these ladies have.

    Diet/exercise works almost 20% better than Metformin to prevent diabetes. Just get rid of the hfcs, keep it low with sugar and white starches.
    There are literally NO side effects. As anyone can tell, I'm not selling anything.
    :-)http://www.webmd.boots.com/diabetes/news/20091029/diet-better-than-drugs-to-prevent-diabetes

    How to cut your blood glucose levels...by avoiding High Fructose Corn Syrup, lose the heavy white starches and exercise. http://www.sciencedaily.com/releases/2007/08/070823094819.htm



    "EVERY WOMAN WITH PCOS SHOULD BE ON METFORMIN BECAUSE WE ALL HAVE INSULIN RESISTANCE"-Tara.

    Here she LIES. Later on in this blog, I post another picture of her crying about her nausea.

    FALLACY: Tara begs the question, appeals to ignorance, hasty generalization, she totally misses the point (we want to be cured, not sold a pill that doesn't work) and a possible false dichotomy.




    "METFORMIN IS NOT A CURE ALL DRUG, BUT EVERYBODY WITH PCOS SHOULD BE ON IT. "-Tara and her fallacies again.


    Who in the right mind would voluntarily make themselves sick to their stomachs when we don't have to?

    Whatever Tara, they took the word "GULLIBLE" out of the dictionary.

    I'm nowhere near diabetic. You shouldn't take Metformin if your liver and kidney is in bad shape. I don't know how this monster has an audience. Since then, I've removed myself from the group, wished Tara well and told her that her shilling was tacky. It's not just tacky, it's unethical.

    Anyone who is combating insulin resistance/cholesterol/diabetes II and not preaching the horrors of high fructose corn syrup is a FAKE. If it's that much of a problem, the one thing you want to do is cut HFCS out of your diet.

    Let's see, how many phonies and fakers are there on this Facebook page?

    Did Christy actually lose 160 pounds? REALLY? I never weighed that much.

    She says that "With those two medications (Byetta and Metformin), my body makes on the insulin I need, absorb the glucose...".

    Metformin just eliminates the extra glucose in your blood. It does not increase insulin, it does not increase glucose absorption. Byetta causes the insulin to be increased within your pancreas. It does NOT increase insulin sensitivity.


    By the way, without the drugs-
    "Glucose, Mannose, B-keto acids, Amino acids( Leucine, Arginine and others) are the food components that increase insulin secretion Glucose is the most important stimulatory agent of insulin secretion, as it is always present in the blood, its concentration is kept within a narrow range and its amounts consumed by humans are the largest ones amongst all nutrients...

    ...Some foods like Garlic and Onions can decrease blood sugar by competing with Insulin for Insulin inactivating sites in the liver, and this results in increase in free Insulin in the blood and this Insulin decreases blood sugar.

    Ginseng herb has been shown to increase the release of insulin from the pancreas and to increase the of Insulin receptors, i.e. it enhances the effect of Insulin in decreasing blood sugar."

    Funny how Christy, our poor case who lost 160 pounds has absolutely NO idea on nutrition that will increase insulin sensitivity. Everybody I know that has dealt with any medical complication knows the tricks in and out. It's because they're really suffering and they learn this out of desperation to feel better. Every grand mal epileptic I've met knows their drugs and nutritional needs- one of them knows the ingredients of her food like the back of her hand. Every Type I diabetic I've met KNOWS their drugs and nutrition backwards and forwards. Not just the drugs, but nutrition. They're less severe cases than our Moderator Christy claims to be, and they're literally a book of cures with their own conditions. And elaborate stories about hospital stays, drugs, needles, etc.. it's not all bad, some of them have a sense of humor too!

    Sara Ouellette is the only one who gave any real advice here.


    Nobody bothered to mention that Metformin causes a Vit B12 deficiency either.

    So Metformin is a mood enhancer? ooookay!

    You lose weight on Metformin due to the nausea. It's the same exact reason why you lose weight on chemotherapy. No cancer patient recommends chemotherapy as a weight loss treatment with this kind of enthusiasm!

    You might as well be bulimic. Losing weight due to nausea, vomiting and other gastrointestinal fun isn't any healthier than bulimia! I'm not a doctor. I hate puking too so I'm the last one that would become bulemic or recommend it. But bulimia sounds like a lot more fun than Metformin, at least you can eat what you want with bulimia.

    Has anyone seen "Flowers in the Attic"? Or Misery?
    These Metformin shills are THAT creepy.



    15 pounds in 2 weeks is what? 7.5 per week? Nausea can do that to you. Unfortunately some of us non-Insulin Resistant people are still nauseas from the cramps.



    Not one word mentioned about inflammatory issues, nothing about T-cells, C-reactive proteins,
    Il-6, free radicals (which causes these cysts)... autoimmune disorders...NADA. This biochemistry stuff is "sooooo boring". Obviously BMY thinks so which is why they don't want to make the effort to cure inflammation caused by free radicals So bandaids like Metformin will have to do for now!
    Per the bad liar Tara AGAIN: "Usually going on Metformin will help with the spots, and calm down the hair growth and restore periods."

    No it doesn't. Metformin just eliminates glucose out of your blood. These hair issues are a result of an inflammatory cause and the spotting... iodine/Vit B. I'm serious.

    Again, I don't know these people but sometimes we talk.
    This one says,

    and on a side note, metformin needs no 'push' from corners..it's use as an antidiabetic agent is undisputed and succesful...it's among the first and second line agents for newly diagnosed diabetics. they already have a huge market for metformin users in the form of diabetics...for PCOS, knowing that nothing cures it, any help in the form of drugs, will be welcomed by the medical community....
    I'm staying far far away from Pakistani doctors.



    Now here's some fun with the site moderator. These people are epic in their push for Metformin, which has been proven to do absolutely NOTHING for PCOS. She lost 50 pounds in 4 months!!!


    TARA HAD A "CHEMICAL PREGNANCY" AND IT FAILED (according to a later post).


    Here I mention the corn syrup. I really mean it when I call it "poison".

    Per Angi, "if you are PCOS then you are indeed Insulin Resistant" (IR abbreviated).

    REALLY?

    That's an absolutist statement if I've ever heard one. And it's FALSE.


    My glucose was 86, if that didn't meet anybody's guidelines then they need to change the guidelines. http://pcos.insulitelabs.com/blog/104/what-works-for-me/

    If you can't see the picture below, you can click on it to enlarge it.
    This is what it says:

    Quote Originally Posted by aranae View Post
    I just got diagnosed with PCOS and low thryoid last week and low Vit. D. I've had high cholesterol my whole life no doc has ever seemed concerned. 4 years ago I was having irregular bleeding and i had an ultrasound done and it showed that both ovaries had mutliple follicles but my gyn. perhaps didn't know what PCOS was or didn't say anything. she wanted to put me on fake hormones/birth control I said no. I had a D&C done for my thickened lining and small polyp and things got better. I also started taking natural progesterone cream and that's helped with the menstrual pain alot but not really anything else.

     I have had irregular cycles and very painful periods my whole life. I didn't have problems with my skin breaking out till I guess the last 10 years (I'm 33).
    I am not overweight because I try to follow the Paleo lifestyle of eating but I have been overweight in the past- I do have a bit of a tummy that I wish I didn't have and extra weight on my hips and butt that I would also like to get rid of. I'm 5'6 and weigh 140.

     I'm glad to know my thryoid is part of the reason I've been too tired to work out consistently. My adrenals crashed 3 years ago and my cortisol levels have returned to a somewhat normal level but I''m still not back to feeling normal. My doc put me on Armour- I hope I will have the energy to work out 3-5 times a week like I used to. My doc also wanted to put me on Metformin and Spironolactone but I don't want to take prescription meds forever, I want to treat the CAUSE not just the symptoms.

     I hope this system will work for me to reverse my fatigue and help my thryroid and weight loss efforts!
    "Glad to hear you got properly diagnosed. And also it's very good that you already worked on your adrenals, because addressing hypothyroidism if the adrenals aren't functioning well is difficult and counterproductive. If your cortisol levels are back to normal and adrenals working well, hopefully the Armour will really help you feel better! There are also many nutrients that can assist thyroid function. Are you seeing a naturopathic doctor, by any chance? If the Armour doesn't help, another option is compounded thyroid hormone. What you'd do is have your doctor test free T3 and free T4, then the doctor talks to a compounding pharmacist and they come up with a personalized prescription combining both T3 and T4. Armour naturally has both too, just the mix is not as predictable as a compounded product... but Armour does work beautifully in many people!
    I am excited that you are trying the Insulite PCOS System. If you have any issues or just need some support, please email us anytime. Sounds like the diet won't be a problem since you are accustomed to the Paleo Diet, so that's a good head start. Hopefully you will be able to discontinue the Metformin and spironolactone after a few weeks or months on the Insulite PCOS System. (Always chat with your doctor before weaning off meds!) One more note, be sure to take the GlucX and really any supplement separately from the thyroid medication (and take the GlucX separately from any other medication too).
    Write back any time and best of luck. We'd love to be updated on your progress."







    Insulite Labs sells their own supplements. Online. Without disclosing what is in the supplements before you buy them. I can't even shop for food or medicine without knowing the ingredients. And I'm supposed to buy this product without knowing what's in them? Is there a warranty?

    Has anyone gone vitamin shopping lately? You have to read a lot of labels. This strategy seems kind of sketchy. They're making all of these promises, yet they can't admit that PCOS IS NOT CAUSED BY INSULIN RESISTANCE. So I don't trust them already.

    Some people would rather be nauseas than avoid chemicals. Hey, if that's her thing- indulge. The "metformin cures all" hackery is going to be the joke of the century though.




    With a little disclaimer right here, I want to defend her religion. I believe she is a Mormon? I don't mean to cyberstalk, but this individual is fascinating. Some people are weirded out by the intensity of the denomination, for others it's a little time consuming and involved. I know because one of my best friends grew up a Mormon. My friend is a nice, intellegent, humble, levelheaded person.

    When I stumbled across this blog, I thought this guy was either some sort of far right Protestant (think Sarah Palin) but his explanation of autoimmune disease (INCLUDING PCOS) was very accurate. http://www.absolutetruthexposed.com/ This man is a Mormon too, his attitude towards PCOS and infertility is actually much more tolerant AND HONEST than the women with PCOS themselves. They know what PCOS is, they know it's an endocrine issue. Tara isn't the only Mormon who ever had an infertility issue. And even still. The Mormons I know, personally would go out of their way to make you feel better. Yes they believe in procreation, but a lot of times their attitude is a helpful one towards a woman who can't have kids. I also know a Mormon with another issue who can't conceive, she's married to a divorced man and raising his kids. They're not running around condemning others, as a group they're not like that.
    So from my own experience, I'm really having a hard time relating to this moderator.


    Tara's comments here could explain everything.

    Why am I in this white robe? Why am I chained to the walls? Ooooh, I like these little white pills! For sure Metformin is the best anti-depressant ever.
    We're going to be on this drug for the rest of our lives!!!

    She's not just bipolar, she's a pathological LIAR.

    The fallacies and shameless shilling is kind of in violation of some medical code of ethics
    (hence the epiphany with America's healthcare system).

    (1) The patient has the right to receive information from physicians and to discuss the benefits, risks, and costs of appropriate treatment alternatives. Patients should receive guidance from their physicians as to the optimal course of action. Patients are also entitled to obtain copies or summaries of their medical records, to have their questions answered, to be advised of potential conflicts of interest that their physicians might have, and to receive independent professional opinions."
    http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion1001.shtml

    Opinion 9.095 - The Use of Patents and Other Means to Limit Availability of Medical Procedures

    Physicians have ethical responsibilities not only to learn from but also, when possible, to contribute to the total store of scientific knowledge. Physicians should strive to advance medical science and make their achievements known through publication or other means of disseminating such information. This encourages physicians to innovate and to share ensuing advances.

    The use of patents, trade secrets, confidentiality agreements, or other means to limit the availability of medical procedures places significant limitation on the dissemination of medical knowledge, and is therefore unethical. (V, VII)    http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion9095.shtml

    "greater safeguards against conflicts of interest are needed to ensure the integrity of the research and to protect the welfare of human subjects."    http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion80315.shtml

    Unethical conduct that threatens patient care or welfare should be reported to the appropriate authority for a particular clinical service.
    http://www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion9031.shtml

    Edward Bernays is rolling in his grave.
    Here's a list of doctors who get kickbacks from Big Pharma.
    http://projects.propublica.org/docdollars/companies
    http://pcossurvivor.blogspot.com/2011/03/reality-stumps-theories-stated-by.html
    http://www.moneydrivenmedicine.org/index.php?start=3
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